Continuous Glucose Monitors Face-off: Dexcom G8 vs. Medtronic Guardian 4
VitalFiberOne Naturals Inc. • May 21, 2025
Continuous Glucose Monitors Face-off: Dexcom G8 vs. Medtronic Guardian 4

Continuous Glucose Monitors (CGMs) have transformed diabetes management by providing real-time glucose data, reducing the need for fingersticks, and enabling proactive treatment decisions. Among the leading CGMs are the Dexcom G8 and Medtronic Guardian 4, each offering unique features tailored to different user needs. This comprehensive comparison delves into their specifications, usability, accuracy, and integration capabilities to help you make an informed choice.
Dexcom G8: Next-Generation Simplicity and Integration
The Dexcom G8 represents Dexcom's latest advancement in CGM technology, building upon the strengths of its predecessors.
Key Features
Sensor Wear Time: 14 days
Warm-Up Period: 30 minutes
Calibration: Factory-calibrated; no fingersticks required
Accuracy: Mean Absolute Relative Difference (MARD) of 8.2%
Integration: Compatible with various insulin delivery systems and health apps
Alerts: Customizable high and low glucose alerts
Data Sharing: Real-time data sharing with caregivers via the Dexcom Follow app
integrateddiabetes.com
The G8's streamlined design and direct integration with smart devices, including Apple Watch, offer users a seamless experience. Its improved accuracy and reduced warm-up time enhance user confidence and convenience.
Dexcom
Medtronic Guardian 4: Precision and Pump Integration
The Guardian 4 sensor is Medtronic's latest CGM, designed to work in tandem with their insulin pump systems, particularly the MiniMed™ 780G.
Key Features
Sensor Wear Time: 7 days
Warm-Up Period: 2 hours
Calibration: No fingersticks required
Accuracy: MARD of 10.6%
Integration: Seamless integration with Medtronic insulin pumps
Alerts: Predictive alerts for impending highs and lows
Data Sharing: Data viewable via CareLink™ Connect app
The Guardian 4's strength lies in its integration with Medtronic's insulin pumps, enabling automated insulin delivery adjustments based on real-time glucose readings. This closed-loop system aims to maintain glucose levels within the target range more effectively.
Side-by-Side Comparison
Feature Dexcom G8 Medtronic Guardian 4
Sensor Wear Time 14 days 7 days
Warm-Up Period 30 minutes 2 hours
Calibration No fingersticks required No fingersticks required
Accuracy (MARD) 8.2% % 10.6%
Integration Multiple insulin delivery systems Medtronic insulin pumps only
Alerts Customizable alerts Predictive alerts
Data Sharing Dexcom Follow app CareLink™ Connect app
Pros and Cons
Dexcom G8
Pros:
Longer sensor wear time reduces the frequency of replacements.
Shorter warm-up period allows for quicker data availability.
High accuracy enhances trust in glucose readings.
Broad integration with various devices and apps offers flexibility.
Cons:
Integration with insulin pumps may require additional setup.
Availability may vary by region and healthcare provider.
Medtronic Guardian 4
Pros:
Designed for seamless use with Medtronic insulin pumps, enabling automated insulin delivery.
Predictive alerts provide early warnings for glucose excursions.
No calibration required simplifies daily use.
Cons:
Shorter sensor lifespan necessitates more frequent replacements.
Longer warm-up period delays initial data availability.
Limited integration with non-Medtronic devices reduces flexibility.
Dexcom
User Experience and Testimonials
Users of the Dexcom G8 appreciate its ease of use, accuracy, and the convenience of real-time data on their smart devices. The ability to share data with caregivers offers peace of mind, especially for parents of children with diabetes.
Medtronic Guardian 4 users value the integration with Medtronic insulin pumps, noting improved glucose control and reduced manual interventions. However, some users mention the shorter sensor lifespan as a drawback.
Conclusion
Both the Dexcom G8 and Medtronic Guardian 4 offer significant benefits for diabetes management, but they cater to different user preferences and needs.
Choose Dexcom G8 if you prioritize longer sensor wear time, quick setup, high accuracy, and flexibility in device integration.
Choose Medtronic Guardian 4 if you are using or plan to use a Medtronic insulin pump and desire a fully integrated system with automated insulin delivery.
Your choice should align with your lifestyle, treatment goals, and the devices you currently use or plan to use.
Have you used the Dexcom G8 or Medtronic Guardian 4? Share your experiences and insights in the comments below. For more in-depth reviews and comparisons of diabetes management technologies, explore our other blog posts.

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